ROLE SUMMARY

Pfizer ORU (Oncology Research Unit) is seeking a highly capable, enthusiastic and motivated Scientist to join the Protein Solutions team. The Protein Solutions team is an integral part of Protein and Bioanalytical Sciences (PBS) group within ORU ADC Discovery. This multidisciplinary team is at the forefront of producing recombinant proteins and antibodies for the development of antibody-drug conjugates (ADCs) and this scientist will play a critical role in supporting the preclinical efforts in developing novel ADC therapeutics.

KEY RESPONSIBILITIES

• Strong focus on integration and optimization of reagent (DNA & Protein) registration and inventory systems

• Development of tools and applications to facilitate requests and support queue efficiencies

• Collaboration with scientists to generate protein reagents to support research projects

• DNA sequence design, vector construction, & nanopore sequencing

• Production of recombinant proteins (including antigens, antibodies, bi-specifics, fusion proteins and small format binders) via mammalian expression and affinity purification

• Analytical and functional characterization of purified products

• Independent design and optimization of experiments

• Data analysis, report generation and presentation of results; including technical reports, patent documentation and tracking of reagents and requests

• Mentor/teach standard practices for protein production and characterization to lab colleagues

BASIC QUALIFICATIONS

• M.S. plus 4 or B.S. plus 6 years' experience; both with 2 of those years in the biopharmaceutical industry; or related discipline

• Demonstrated experience with using, building and optimizing registration and request workflows

• Proficient in recombinant protein expression via mammalian cells and protein purification using liquid chromatography techniques

• Expertise in molecular biology techniques; including design, PCR, mutagenesis, subcloning, and sequence analysis

• Experience in evaluating protein product quality; including, analytical chromatography and mass spectrometry

• Ability to perform routine tasks independently and commitment to high quality analysis and documentation

• Team player with a strong record in collaboration and excellent written/oral communication skills

• Detail-oriented with strong analytical, organizational, and multi-tasking skills

• Flexibility and prioritization skills to meet personal and group goals

PREFERRED QUALIFICATIONS

• Design and implementation of novel fusion, small-format and bispecific methods and technologies

• Knowledge of antibody sequence structure, germlines, isotype, alleles and common variants to modify Fc function.

• Understanding of cancer biology and experience with oncology drug development

• Familiarity with developability and biophysical characterization assays

• Experience with high throughput and automated lab equipment and assays

Additional Information:

• Work Location- On Premise

• Last Day to Apply: January 1, 2025

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development