The Department of Medicine, Division of Pulmonary and Critical Care Medicine within the School of Medicine at The University of Virginia is seeking a junior faculty member to join us working on the integrative projects under the mentoring and supervision of Dr. Anny Xiaobo Zhou, the Director of Center for Translational Genomics Initiative in Respiratory Diseases. The research goals of the Center are to determine the function of genes identified by genome-wide association studies (GWAS) in respiratory diseases, including asthma, Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF), particular on genes that regulate cellular energy metabolism thereby determining the stemness of alveolar epithelial progenitors.

We combine ex vivo lung organoid models, in vivo lineage tracing and lung slices to evaluate functional impacts of novel GWAS genes. We are interested in how these novel GWAS genes, expressed in either alveolar progenitors or niche cells, determine alveolar epithelial repair/regeneration, modulate lipid and/or glucose metabolism, regulate RNA modification and fine-tune innate immune response in epithelial progenitors intrinsically and through cell-cell communications. Additional translational projects will involve in vivo delivery of compounds, drugs, siRNA or nanoparticles targeting these novel GWAS genes for therapy.

Senior post-doctoral fellows who are passionate about science and with solid knowledge and strong skills related to CRISPR editing, epithelial biology, organoid models, cellular metabolism and innate immune response are strongly encouraged to apply. You will work in a dynamic and interdisciplinary research area. We also encourage applications from candidates with combined skills in molecular biology and analytic skills for next generation sequencing data.

• Education: PhD in Biology and Biomedicine related field

• At least five years of post-doc experience with strong publication record preferred.

Please visit http://apply.interfolio.com/161725 to apply and submit all required documents.

The university will conduct background checks and health screenings on all new hires prior to employment.

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