Genomics Clinical Variant Analyst II - Next Generation Seq Requisition ID 2024-53827 Category Research Overview The Genomic Clinical Variant Analyst II is part of the Genomic Clinic Analysis Team (GCAT), responsible for accurately identifying and classifying variants within the Steve and Cindy Rasmussen Institute for Genomic Medicine. The Variant Analyst II will review and document variants following practice guidelines under the direction of the Laboratory Directors and Variant Scientists. The Variant Analyst II will assist with the day to day operations of variant assessment, curation, and documentation to accurately identify and classify genomic alterations detected through genomic testing and translational studies. Why Nationwide Children's Hospital? The moment you walk through our doors, you feel it. When you meet our patient families, you believe it. And when you talk with anyone who works here, you want to be part of it. Welcome to Nationwide Children's Hospital, Where Passion Meets Purpose. Here, Diversity, Equity and Inclusion are integrated into our core values and practices. We are passionate about building, sustaining and evolving an inclusive and equitable environment. We are seeking individuals who live these values and want to share their experiences and efforts in support of our collective mission. We're 14,000 strong. And it takes every one of us to improve the lives of the kids we care for, and the kids around the world we'll never meet. Kids who live healthier, fuller lives because of the knowledge we share. We know it takes a Collaborative Culture to deliver on our promise to provide the very best, innovative care and to foster new discoveries, made possible by the most groundbreaking research. Anywhere. Ask anyone with a Nationwide Children's badge what they do for a living. They'll tell you it's More Than a Job. It's a calling. It's a chance to use and grow your talent to make an impact that truly matters. Because here, we exist simply to help children everywhere. Nationwide Children's Hospital. A Place to Be Proud. Responsibilities PRINCIPAL DUTIES AND RESPONSIBILITIES Understands and demonstrates Nationwide Children's Hospital Staff Core Competencies. Performs technical and quality review of molecular genomic data, including troubleshooting, where needed. Demonstrates ability to provide accurate and timely variant assessment according to established workflows and criteria based on the American College of Medical Genetics and Genomics (ACMG) guidelines as well as the Association for Molecular Pathology (AMP), American Society of Clinical Oncology (ASCO), and College of American Pathologists (CAP) guidelines for the interpretation and reporting of sequent variants in cancer. Demonstrates ability to provide accurate evaluation and interpretation of published literature and clinical data, including correlation of the variant and gene with patient phenotype, or disease state. Maintains ongoing knowledge of current theories and principals of human medical genetics, cancer genetics and hereditary cancer disorders. Assists with research, development, validation, and documentation of new genomic assays. Thoroughly documents findings, per laboratory standard operating procedures. Utilizes a variety of packaged and in-house software tools to perform research and generate clinical reports. Performs quality control functions for laboratory workflow processes. Demonstrates self-management skills. Demonstrates the ability to work efficiently and independently, promoting a team environment and maintaining a cooperative and supportive atmosphere. Demonstrates knowledge of and upholds applicable laws and regulations related to position and clinical laboratories. Maintains knowle