The mission of the Mass Spectrometry Research Center (MSRC) is to bring state-of-the-art mass spectrometry expertise, methodology, and instrumentation to researchers at Vanderbilt University and Vanderbilt University Medical Center. The Schey lab occupies 2,500 square feet of laboratory space, and has two LC-MS/MS instruments, including one LTQ Velos ion trap and a Waters Xevo G2S QTOF instrument with HDX capabilities. Support for the laboratory comes from NIH- and ARPA-H funded projects.

Duties and Responsibilities

Research

• Execution of HDX-MS and XL-MS workflows

• Follow specific workflows for sample preparation, including deuterium labeling, protein crosslinking, protein digestion, and sample clean-up

• LC-MS/MS instrument operation and acquisition of HDX-MS data

• Data analysis of HDX-MS and XL-MS data

• Generate reports of HDX-MS and XL-MS data, including visualization tools and protein structure figures

Instrument Management

• Daily operation and routine maintenance of state-of-the-art LC-MS/MS instrumentation

• Operation of instrument software for instrument calibration and data acquisition

• Performance of instrument QA/QC procedures

Maintenance

• Routine laboratory maintenance

• Supply ordering

• Data management

• Record-keeping

• Chemical waste disposal

Qualifications

• PhD in physical or biological sciences is required.

• At least two years of post-graduate experience required, five years of experience is preferred.

• Laboratory experience in proteomics, biochemistry, or analytical chemistry is required.

• Experience in protein/peptide analysis using HPLC tandem mass spectrometry (LC-MS/MS), and mass spectrometry data analysis is required.

• Strong organizational skills is preferred.

• Ability to learn and assist in development of new protocols in an evolving field is required.

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