Job Description

Title: Postdoctoral fellow

Salary: According to union/Sinai policy, starting salary: $73,588

Department: Cardiovascular Research Institute

Physical work location: (must be proper street address) 1470 Madison Ave, 7 th floor, New York, NY 10029

Name PI or Supervisor: (include phone and email) Dr. Cameron McAlpine, Cameron.mcalpine@mssm.edu , 857-207-8093

Web link to Lab: https://labs.icahn.mssm.edu/mcalpinelab/

Web link to Department: https://icahn.mssm.edu/research/cardiovascular

Administrative Contact: (phone and email) Chris Chan, 212-241-4080, chrisptopher.chan@mssm.edu

Qualifications

Educational and other Requirements for the position: PhD

Experience Required: No experience beyond PhD

Goals/Outcomes of the Research Project: The goal of the project is to delineate how T-cell-mediated heart-brain signaling after MI influence neurocognitive outcomes. The postdoc will publish his data in leading journal and disseminate his findings at internal and external conferences.

Compensation Statement

The Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for this role is $73,588.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), J16 - Cardiovascular Research Institute - ISM, Icahn School of Medicine

EOE Minorities/Women/Disabled/Veterans

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”

Responsibilities

Details of Research Project:

The postdoctoral fellow will study how T-cells in the brain influence cognitive decline after myocardial infarction. Myocardial infarction (MI) is a leading cause of preventable death worldwide. Although treatment for MI has vastly improved, the increased survival of MI patients has led to the development of secondary complications such as, arrythmias, heart failure and vascular dementia (VaD), which can develop many years after a cardiac event. Furthermore, MI patients commonly present with behavioral and neurological changes following MI, including increased anxiety, depression and cognitive decline. Despite these associations, the mechanisms that link MI with neurovascular, neurological and cognitive changes remain poorly understood. Exploring MI-driven neurological changes will open new treatment avenues to improve the quality of life for surviving MI patients. Our preliminary data suggest T-cells influx the brain after experimental MI and alter cognitive decline and behaviors.

Technical Duties: (include any protocols)

The postdoc will use the techniques of flow cytometry and immunofluorescent imaging of tissue sections. Briefly, for flow cytometry, the student will prepare a single cell suspension of mouse brain tissue, stain the cells with antibodies and analyze the sample using an Auror Cytek flow cytometer. Data will be visualized and analyzed using FlowJo software to identify function and phenotypes of immune cells. For immunofluorescent imaging, brain sections will be stained with antibodies and imaged on a microscope. The morphology and function of immune cells in the brain will be analyzed. Behavioral and cognitive tests will include the Y-maze, the barnes maze, social interaction, and elevated plus maze.

About Us

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

• Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.

• Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.

• Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.

Explore more about this opportunity and how you can help us write a new chapter in our history!

“About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”

EOE Minorities/Women/Disabled/Veterans

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.