Position Objective: Provide services as a Process Chemist in support of the overall functions of the National Center for Advancing Translational Sciences within the National Institutes of Health (NIH). The purpose of this position is to possess a deep knowledge of scale-up and process chemistry skills for the development of safe and scalable synthetic routes, with early and late-phase development experience and delivering drug substances under tight timelines.

Duties and Responsibilities:

• Perform bulk-synthesis, purification and formulation efforts for advanced testing in animal models. 3

• Perform chemical and biochemical reactions and appropriate analytical analyses. 5

• Design and develop safe and scalable processes for organic compounds of specicific therapeutic targets 1

• Purify organic compounds using a variety of techniques including chromatography, extraction, distillation, crystallization, trituration,etc. 4

• Synthesize key intermediates and drug substances from gram to kilogram scale. 2

• Perform general maintenance and upkeep of equipment and instrumentation.

• Troubleshoot and provide routine maintenance of the instruments and equipment.

• Identify the cause of common problems and mistakes and make necessary repairs.

• Documents and analyzes results, produces detailed summaries and reports.

• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals.

• Maintain up-to-date electronic laboratory notebook detailing all experiments.

• Collect and review data; analyze and interpret data and results.

• Produce research reports and communicate results.

• Search chemical databases for journal articles, patents and related technologies.

• Manage bulk-synthesis, purification and formulation efforts for advanced testing in animal models.

• Work with staff in identity, purity and stability analysis.

• Analyze and characterize organic compounds using state-of-the art analytical technologies;

• Purify compounds by preparative chromatography from chemists.

• Perform bulk-synthesis, purification and formulation efforts for advanced testing in animal models.

• Perform chemical and biochemical reactions and appropriate analytical analyses.

• Design and develop safe and scalable processes for organic compounds of specicific therapeutic targets

• Synthesize key intermediates and drug substances from gram to kilogram scale.

• Purify organic compounds using a variety of techniques including chromatography, extraction, distillation, crystallization, trituration, etc.

• Maintain and provide updates on laboratory stockroom and equipment maintenance.

• Inventory all chemicals; maintain and provide updates on all shipping and receiving requests.

• Keep an active inventory of all chemicals kept in the laboratory.

• Maintain computer database for various records..

• Develop new analytical and separation techniques for the solution of scientific questions.

• Develop and document new procedures.

• Develop novel chemistry methodologies and technologies that advance the field and make recommendations.

• Collaborate with staff to evaluate and/or develop new techniques.

• Perform comparative studies with older technology. Perform evaluations to determine new guidelines.

• Develop and present plans for novel syntheses and approaches to new compounds.

• Develop experimental procedures and research protocols.

• Train staff on new experiments, practices, operation and maintenance of instruments and equipment and safety practices.

• Train junior laboratory staff in the design and execution of proper chemical/biochemical protocols.

• Maintain and perform training on scientific instrumentation and equipment.

• Work with staff on all mandatory training and competency assessments.

• Organize and mentor staff in the use of instrumentation.

• Work with facilities manager on evacuation procedures and drills.

• Develop and document new procedures.

• Develop novel chemistry methodologies and technologies that advance the field and make recommendations.

• Perform comparative studies with older technology. Perform evaluations to determine new guidelines.

• Perform evaluations to determine new guidelines.

• Develop and present plans for novel syntheses and approaches to new compounds.

• Develop experimental procedures and research protocols.

• Work with staff to monitor and manage waste disposal.

• Monitor and report on all safety issues.

• Carry out periodic lab surveys; dispose of radioactive and chemical waste according to Institutional and regulatory procedures.

• Participate in laboratory clean-up events and aid laboratory managers in organizing stock-rooms and bench areas.

• Maintain staff safety records for compliance.

• Maintain records or quarterly safety inspections.

• Coordinate laboratory and network obligations.

• Design synthetic routes to target molecules.

• Synthesize, purify and characterize target molecules.

• Provide chemistry support for multiple projects.

• Present research findings at group meetings, project meetings and conferences.

• Coordinate projects being developed by external collaborators, propose SAR strategies and monitor their progress.

• Perform a variety of chemical techniques and advanced analysis to complete studies and experiments.

• Develop new analytical and separation techniques for the solution of scientific questions.

• Perform general maintenance and upkeep of equipment and instrumentation.

• Troubleshoot and provide routine maintenance of the instruments and equipment.

• Monitor, troubleshoot and initiate or take corrective action to maintain instrument function and quality.

• Identify the cause of common problems and mistakes and make necessary repairs.

• Develop experimental procedures and research protocols.

• Develop novel chemistry methodologies and technologies that advance the field.

• Collaborate with staff to evaluate and/or develop new techniques.

• Carry out scale-up of the chemical probes of interest for additional studies.

• Maintain a comprehensive notebook and analytical data for each compound synthesized.

• Interpret data; use evolving activity and data to design additional rebounds of analogs.

• Conduct and write literature reviews for current and future projects.

• Collect and review data; analyze and interpret data and results.

• Search chemical databases for journal articles, patents and related technologies.

• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals.

• Prepare summaries, reports and presentations based on findings.

• Contribute to publications and patent writing.

• Produce research reports and regularly communicate results.

• Search chemical databases for journal articles, patents and related technologies.

• Clean Equipment.

• Inspect Equipment.

• Meet with lab members to present updates.

  Basic Qualifications:

• Master’s Degree in Chemistry or a related field of study.

• Certified in Good Manufacturing Practice (GMP).

• Skilled in process development and scale-up synthesis, chromatography (HPLC, GC. etc), nuclear magnetic resonance, equipment maintenance, and manuscript writing.

• Skilled in MS Office, E-Notebook, Chemdraw, and MestReNova.

  Minimum Qualifications:

• Ability to multi-task and pay close attention to detail.

• Excellent analytical, organizational and time management skills.

• Strong communication skills, both oral and written.

  *This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.

  To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

  GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job us at recruiting@gapsi.com . You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note, this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.

  GAP Solutions is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to their race, ethnicity, ancestry, color, sex, religion, creed, age, national origin, citizenship status, disability, medical condition, military and veteran status, marital status, sexual orientation or perceived sexual orientation, gender, gender identity, and gender expression, familial status, political affiliation, genetic information, or any other legally protected status or characteristics.

  This position is contingent upon contract award.

Requisition ID: 7244